From $6,150 per person
7 days
Ship: National Geographic Quest
Day-by-day description of your cruise and cruise activities.
Panama City, Panama / Colón / Embark Ship
Arrive in Panama City, the capital of Panama this afternoon and transfer to Colón to embark the <i>National Geographic Quest </i>this evening. Meet your expedition staff and enjoy a traditional Congo music and dance performance. You may opt for a culturally-immersive <a href=https://www.expeditions.com/extensions/panama-city-and-san-lorenzo-pre-extension>pre-voyage extension in Panama City and San Lorenzo</a>, a UNESCO-designated World Heritage Site.<b>Arrival Time: </b>Arrive by 12:00 p.m. <br /><b>Arrival City: </b>Panama City, Panama
Portobelo / Panama Canal Transit
This morning, explore the area on kayaks, stand-up paddleboards, Zodiac cruises upriver, or go for a snorkel. Portobelo is known for its Spanish colonial military architecture, which is designated collectively as a UNESCO World Heritage site. Visit several of the fortifications as well as the old Customs House, and hear the tales of Portobelo’s rich pirate history. Later on, set sail for the Panama Canal. As cargo ships tend to pass through the canal during the day, you'll most likely begin your crossing at night, when the canal is dramatically lit. By special arrangement, <i>National Geographic Quest</i> will anchor in Gatún Lake near the Barro Colorado Nature Monument overnight.
Gatún Lake / Panama Canal Transit
Today, choose hikes and Zodiac cruises at the Smithsonian Tropical Research Institute facility on Barro Colorado Island, or take a boat ride to Gamboa, where the Chagres River meets the Panama Canal, and hike on the Panama Rainforest Discovery Center trails. This evening, continue through the complex lock system of the Canal and venture into the Gulf of Panama.
Punta Patiño Nature Reserve
This morning, arrive along the coast of the Darién Province. Punta Patiño Nature Reserve is Panama’s largest private nature reserve and boasts a rich tapestry of habitats that foster biodiversity. Today you will reach the local beaches by Zodiac. Overhead, search for a variety of birds including mangrove hawks, laughing falcons and roseate spoonbills, or, by land, look for crab-eating raccoons and crocodiles. Additional opportunities may be available to walk the beach, kayak in the shallow bay or continue to explore by Zodiac.
Playa Muerto, Darién National Park
Playa Muerto village is located in Darién National Park, the largest protected area in Central America and a UNESCO World Heritage site. The park contains an exceptional array of habitats, from sandy beaches and mangroves to dense tropical forests teeming with wildlife. It is also home to the indigenous Emberá and Wounaan tribes. You’ll be greeted by village leaders from the Emberá who will share their customs, traditions and stories about their deep respect for their natural surroundings. Later on, enjoy short nature walks, go birding or choose to join a longer hike into the rainforest in search of the elusive harpy eagle, one of the world’s most powerful eagles.
Pearl Islands
Approximately 200 islands make up the idyllic Pearl Islands. Explore several of the islands in the archipelago, including Isla del Rey and Isla Pacheca, as you learn about the history of the native populations and eventually the Spaniards and African slaves who arrived for the pearl trade. Deep rainforests, lush rivers, white sandy beaches and shallow reefs provide great opportunities for hiking, sea kayaking, stand-up paddleboarding, Zodiac river cruises, beach activities and snorkeling.
Balboa / Disembark Ship / Panama City, Panama
Disembark in Balboa and transfer to the airport in Panama City for flights home. Ask your expedition specialist about enjoying a culturally-immersive <a href=https://www.expeditions.com/extensions/panama-city-and-san-lorenzo-post-extension>post-voyage extension in Panama City and San Lorenzo</a>, a UNESCO-designated World Heritage Site.<b>Departure Time: </b>Depart anytime after 2:30 p.m. <br /><b>Departure City:</b> Panama City, Panama
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Explore North America’s wildest coastal regions aboard the National Geographic Quest, a purpose-built expedition ship that offers an ideal blend of comfort, agility, and immersive discovery. Measuring 238 feet in length and accommodating just 100 guests, this nimble vessel is perfectly suited for exploring Alaska’s Inside Passage, the Pacific Northwest, Baja California, and Central America—reaching remote inlets and secluded shorelines that larger ships simply can’t access.
Designed with exploration in mind, the Quest features 50 outward-facing cabins, many with large windows or sliding glass doors and private balconies. Each stateroom is thoughtfully appointed with modern décor, comfortable bedding, and en-suite bathrooms, creating a welcoming space to unwind after active days in the field. Select cabins offer connecting layouts ideal for families or small groups.
Onboard, guests enjoy a relaxed and sociable atmosphere, with a spacious lounge for lectures and recaps, an open-air observation deck, a wellness area with a fitness center, and a dining room serving fresh, locally inspired cuisine. Regional flavors, sustainable sourcing, and an open seating policy make mealtimes both delicious and convivial.
Equipped with a full expedition toolkit—including Zodiacs, kayaks, paddleboards, a remotely operated vehicle (ROV), and undersea video technology—the Quest is built for hands-on exploration. Each voyage is led by a passionate team of naturalists, marine biologists, and a National Geographic-certified photo instructor, offering daily excursions, expert insights, and up-close encounters with wildlife such as whales, sea lions, bears, and bald eagles.
Whether cruising beside calving glaciers in Alaska or snorkeling with sea lions in the Sea of Cortez, the National Geographic Quest delivers an active, enriching, and deeply personal travel experience—crafted for curious travelers seeking adventure with meaning.
Reach out to our travel concierges today to create your perfect journey.