Panama and Colombia: Exploring the Caribbean Coast

Detailed Itinerary

Day-by-day description of your cruise and cruise activities.

Day 1

Cartagena, Colombia / Embark Ship

Arrive in Cartagena, one of the major port cities of Colombia, and transfer to the National Geographic Quest to begin your journey along the Caribbean Coast.Arrival Time: Arrive before 2:30 p.m. local time.

Arrival City: Cartagena, Colombia

Day 2

Sanguare Natural Reserve / Cispatá Bay

The day begins by exploring Sanguare Natural Reserve. This former cattle ranch, now part of the national system of protected areas, offers great opportunities to explore on foot or by water. Learn of the conservation work being done and explore the tropical dry forests, coastal lagoons, and sea grass beds. Enjoy kayaking or paddleboarding, or dig your toes in the sand and sip a chilled refreshment.

After lunch on board, venture to Cispatá Bay, where we’ll spend the afternoon among the most extensive area of mangroves on Colombia’s Caribbean coast. Local community guides accompany us to share their insight and knowledge of the prolific wildlife. Join naturalists from local conservation group Asocaiman as they release rehabilitated young caimans back into the wild.

Day 3

San Antero / Santa Cruz de Lorica / Tuchín

Today we visit Santa Cruz de Lorica on the banks of the Sinú River, a melting pot of cultures from throughout Europe and the Middle East. Stroll the central square and notice how the city’s distinct influences live harmoniously, spotlighted in the architecture of the stunning Spanish-colonial cathedral and historic buildings in colorful Arabic styles. A folkloric show will be performed along the riverfront malecón during our walking tour. We’ll enjoy lunch at a local restaurant before traveling to the nearby indigenous village of Tuchín. Watch craftsmen as they make hats that are considered Colombia’s national symbol, the sombrero vueltiao, and meet the local Zenú, celebrated for their ingenious irrigation systems. Pending conditions, guests may visit Tuchín in the morning, and Santa Cruz de Lorica in the afternoon.

Day 4

Capurgana & Sapzurro, Colombia

National Geographic Quest calls at the wonderfully isolated villages of Sapzurro and Capurgana positioned only 3 miles apart on the stunning coast of Caribbean Colombia. Set out on a nature walk on the Capurgana-Sapzurro trail. In this area, the ranges of two species of howler monkeys overlap as both the mantled and the Colombian red howler monkeys are here. Watch for toucans, parrots, trogons, occasionally scarlet macaws, and possibly three-toed sloths as we traverse the tropical forest trails between the villages. Or choose a shorter hike which takes us across an international, transcontinental frontier to Panama. Pass through the quick, walk-through border crossing perched high on a bluff before descending to the beach at the Panamanian village of La Miel. The sheltered waters of the bay at Sapzurro back in Colombia beckon us for a pleasant kayak or paddleboard around this tropical inlet. We finish our day at sunset in the village of
Capurgana.

Day 5

Guna Yala Archipelago

Wake up and find yourself amidst the Guna Yala archipelago (known also as the San Blas Islands), a scattering of 368 tiny, white-sand isles off the northeast coast of Panama. Spend the day exploring paradise where the Guna people still live as their ancestors did—in thatched huts making ancient handicrafts such as molas, colorful panels of stitched fabric. Deeply committed to their culture, the Guna are admired as a politically autonomous community where women make the rules and gender fluidity is celebrated.In the afternoon, go offshore and explore the vibrant marine world of this breathtaking utopia by snorkel, kayak, and stand-up paddleboard.

Day 6

Portobelo

In the morning, arrive at the historic town of Portobelo, or “beautiful port,” so named in 1502 by Cristopher Columbus and a critical Spanish trading center in the New World. The day here explores 17th- and 18th-century Spanish fortifications, designated a UNESCO site. Later, hike the surrounding jungle in search of native parrots and unruly howler monkeys.

Day 7

Gatún Lake

Special permission allows our ship to anchor overnight in the Panama Canal’s vast Gatún Lake. Disembark in the morning at Barro Colorado, an island formed by the damming of the Chagres River to build the Panama Canal. A visit to the Smithsonian Tropical Research Institute unveils initiatives to protect and study the extraordinary biodiversity of one of our planet’s most studied tropical forests and site of National Geographic studies. Alternatively, engage in the wildness of the region by taking a hike into the jungle, a Zodiac across the vast lake, or a boat ride to the mouth of the Chagres to explore the Panama Rainforest Discovery Center. The luminosity of the evening heightens the drama of your transit through the complex lock system of the legendary Panama Canal, 50 miles long and passage for some 14,000 ships yearly.

Day 8

Panama City, Panama / Disembark Ship

Disembark in Panama City and transfer to the airport for your flight home. Ask your expedition specialist about enjoying a culturally-immersive post-voyage extension in Panama City and San Lorenzo.Departure Time: Depart after 1:00 p.m. local time.

Departure City: Panama City, Panama

Ship

Your cruise ship

About this ship

National Geographic Quest

Explore North America’s wildest coastal regions aboard the National Geographic Quest, a purpose-built expedition ship that offers an ideal blend of comfort, agility, and immersive discovery. Measuring 238 feet in length and accommodating just 100 guests, this nimble vessel is perfectly suited for exploring Alaska’s Inside Passage, the Pacific Northwest, Baja California, and Central America—reaching remote inlets and secluded shorelines that larger ships simply can’t access.

Designed with exploration in mind, the Quest features 50 outward-facing cabins, many with large windows or sliding glass doors and private balconies. Each stateroom is thoughtfully appointed with modern décor, comfortable bedding, and en-suite bathrooms, creating a welcoming space to unwind after active days in the field. Select cabins offer connecting layouts ideal for families or small groups.

Onboard, guests enjoy a relaxed and sociable atmosphere, with a spacious lounge for lectures and recaps, an open-air observation deck, a wellness area with a fitness center, and a dining room serving fresh, locally inspired cuisine. Regional flavors, sustainable sourcing, and an open seating policy make mealtimes both delicious and convivial.

Equipped with a full expedition toolkit—including Zodiacs, kayaks, paddleboards, a remotely operated vehicle (ROV), and undersea video technology—the Quest is built for hands-on exploration. Each voyage is led by a passionate team of naturalists, marine biologists, and a National Geographic-certified photo instructor, offering daily excursions, expert insights, and up-close encounters with wildlife such as whales, sea lions, bears, and bald eagles.

Whether cruising beside calving glaciers in Alaska or snorkeling with sea lions in the Sea of Cortez, the National Geographic Quest delivers an active, enriching, and deeply personal travel experience—crafted for curious travelers seeking adventure with meaning.

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