Panama and Colombia: Exploring the Caribbean Coast

Detailed Itinerary

Day-by-day description of your cruise and cruise activities.

Day 1

Panama City, Panama / Colón / Embark Ship

Arrive in Panama City, the capital of Panama, this afternoon. Transfer to Colón to embark the National Geographic Quest this evening. You may opt for a culturally immersive pre-voyage extension in Panama City and San Lorenzo, a UNESCO-designated World Heritage Site.Arrival Time: Arrive before 1:30 p.m. local time.
Arrival City: Panama City, Panama

Day 2

Portobelo

In the morning, arrive at the historic town of Portobelo, or “beautiful port,” so named in 1502 by Christopher Columbus and a critical Spanish trading center in the New World. Explore 17th- and 18th-century Spanish fortifications, designated a UNESCO site. Later, hike the surrounding jungle in search of native parrots and unruly howler monkeys.

Day 3

Guna Yala Archipelago

Wake up and find yourself amidst the Guna Yala archipelago (known also as the San Blas Islands), a scattering of 368 tiny, white-sand isles off the northeast coast of Panama. Spend the day exploring paradise where the Guna people still live as their ancestors did–in thatched huts making ancient handicrafts such as molas, colorful panels of stitched fabric. Deeply committed to their culture, the Guna are admired as a politically autonomous community where women make the rules and gender fluidity is celebrated. We will also explore the vibrant marine world of this breathtaking utopia by snorkel, kayak and stand-up paddleboard.  

Day 4

Capurgana and Sapzurro, Colombia

National Geographic Quest calls at the wonderfully isolated villages of Sapzurro and Capurgana positioned only 3 miles apart on the stunning coast of Caribbean Colombia. Set out on a nature walk on the Capurgana-Sapzurro trail. In this area, the ranges of two species of howler monkeys overlap as both the mantled and the Colombian red howler monkeys are here. Watch for toucans, parrots, trogons, occasionally scarlet macaws and possibly three-toed sloths as you traverse the tropical forest trails between the villages. Or choose a shorter hike which takes you across an international, transcontinental frontier to Panama. Walk through the border crossing, perched high on a bluff, before descending to the beach at the Panamanian village of La Miel. The sheltered waters of the bay at Sapzurro back in Colombia beckon for a pleasant kayak or paddleboard around this tropical inlet. Finish the day at sunset in the village of Capurgana.

Day 5

Santa Cruz de Lorica / San Antero / Tuchín

Visit Santa Cruz de Lorica on the banks of the Sinú River, a melting pot of cultures from throughout Europe and the Middle East. Stroll the central square and notice how the city’s distinct influences live harmoniously, spotlighted in the architecture of the stunning Spanish-colonial cathedral and historic buildings in colorful Arabic styles. A folkloric show will be performed on the riverfront malecón during your walking tour. Enjoy lunch at a local restaurant before traveling to the nearby indigenous village of Tuchín. Watch craftsmen as they make hats that are considered Colombia’s national symbol, the sombrero vueltiao, and meet the local Zenú, celebrated for their ingenious irrigation systems. National Geographic Quest will remain anchored in San Antero overnight. Pending conditions, guests may visit Tuchín in the morning, and Santa Cruz de Lorica in the afternoon.

Day 6

Cispatá Bay / Sanguare Natural Reserve

The day begins by exploring Cispatá Bay, where you’ll spend the morning among the most extensive area of mangroves on Colombia’s Caribbean coast. Local community guides accompany you to share their insight and knowledge of the prolific wildlife. Join naturalists from local conservation group Asocaiman as they release rehabilitated young caimans back into the wild.After lunch on board, venture over to the Sanguare Natural Reserve. This former cattle ranch, now part of the national system of protected areas, offers great opportunities to explore on foot or by water. Learn of the conservation work being done and explore the tropical dry forests, coastal lagoons and sea grass beds. Enjoy kayaking or paddleboarding, or dig your toes in the sand and sip a chilled refreshment.

Day 7

Cartagena / Disembark Ship

Disembark in Cartagena and transfer to the airport for flights home.Departure Time: Depart after 11:30 a.m. local time.
Departure City: Cartagena, Colombia

Ship

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About this ship

National Geographic Quest

Explore North America’s wildest coastal regions aboard the National Geographic Quest, a purpose-built expedition ship that offers an ideal blend of comfort, agility, and immersive discovery. Measuring 238 feet in length and accommodating just 100 guests, this nimble vessel is perfectly suited for exploring Alaska’s Inside Passage, the Pacific Northwest, Baja California, and Central America—reaching remote inlets and secluded shorelines that larger ships simply can’t access.

Designed with exploration in mind, the Quest features 50 outward-facing cabins, many with large windows or sliding glass doors and private balconies. Each stateroom is thoughtfully appointed with modern décor, comfortable bedding, and en-suite bathrooms, creating a welcoming space to unwind after active days in the field. Select cabins offer connecting layouts ideal for families or small groups.

Onboard, guests enjoy a relaxed and sociable atmosphere, with a spacious lounge for lectures and recaps, an open-air observation deck, a wellness area with a fitness center, and a dining room serving fresh, locally inspired cuisine. Regional flavors, sustainable sourcing, and an open seating policy make mealtimes both delicious and convivial.

Equipped with a full expedition toolkit—including Zodiacs, kayaks, paddleboards, a remotely operated vehicle (ROV), and undersea video technology—the Quest is built for hands-on exploration. Each voyage is led by a passionate team of naturalists, marine biologists, and a National Geographic-certified photo instructor, offering daily excursions, expert insights, and up-close encounters with wildlife such as whales, sea lions, bears, and bald eagles.

Whether cruising beside calving glaciers in Alaska or snorkeling with sea lions in the Sea of Cortez, the National Geographic Quest delivers an active, enriching, and deeply personal travel experience—crafted for curious travelers seeking adventure with meaning.

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